A Multi-centric Study to Assess the Efficacy of Sigmart in Subjects With Recurrent Angina After Coronary Revascularization

Inclusion Criteria: * Subjects should be 18\~70 years old, male or female * Subjects should have a history of coronary revascularization at least 6 months ago * Subjects should present with typical angina or similar to the chest pain before prior coronary revascularization for at least 1 month * Subjects should be relieved from anginal attacks with short-acting NTG * Subjects should have the ability to withhold medication which cannot be concomitant in this clinical study during the study * Subjects should have an ability to give written informed consent Exclusion Criteria: * Unstable angina * Left main coronary artery disease * Aortic stenosis * Obstructive hypertrophic cardiomyopathy * Subjects with hypertension (SBP\>170 mmHg or DBP\>100 mmHg) or hypotension (SBP\<90 mmHg or DBP\<60 mmHg) * Postural hypotension (drop in systolic blood pressure \>20% after 2 minute standing), * Congestive heart failure (NYHA class III - IV) * Ejection fraction (EF)\<45% by Echocardiography * Peripheral arterial obstructive disease or other diseases limiting exercise testing * Arrhythmias requiring active treatment * Gastro-intestinal ulcer * Liver dysfunction (defined as ALT or bilirubin\>1.5×upper limit of normal value) * Significant renal impairment, such as serum creatinine greater than 1.5 folds the upper limit of normal as determined by local clinical laboratory * Glaucoma * Concomitant medication such as Trimetazidine, Sulphonylurea, PDE-5 inhibitor such as sildenafil, Chinese traditional medicine for treatment of angina pectoris * Known intolerance to nitrates * Known allergic to nicotinic acid * Pregnant or lactating women * Any other contraindications mentioned in the SPC * Participation in another clinical study within the last 3 months * Legal incapacity or limited legal capacity * Any other subjects assessed by the investigator as being unsuitable for the present study