Study of Tocotrienol Absorption and Distribution Under Different Fat Status

Malaysia Palm Oil Board10 enrolled

Overview

Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols

There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Absorption

Interventions

TocotrienolDIETARY_SUPPLEMENT

500 mg of tocotrienol will be administered after consumption of high fat diet

TocotrienolDIETARY_SUPPLEMENT

500 mg of tocotrienol will be administered after consumption of low fat diet

Eligibility

Sex: MALEMin age: 22 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male aged 22-25 * body mass index 18.5 \< X \< 30 kg/m2 * plasma cholesterol \< 5.2 mmol/L, * TAG \< 1.7 mmol/L Exclusion Criteria: * history of cardiovascular disease * diabetic * body mass index \< 18.5 or \> 30 kg/m2 * plasma cholesterol \> 5.2 mmol/L, * TAG \> 1.7 mmol/L * hypertension * currently taking Vitamin E supplement * current use of medication * smoking.

Locations (1)

Malaysian Palm Oil Board

Bangi, Selangor, Malaysia

Outcomes

Primary Outcomes

Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol

Time frame: 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal

Data from ClinicalTrials.gov

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