Combined Immunochemotherapy in Patients With T-Prolymphocytic Leukemia (T-PLL)

Inclusion Criteria: * Untreated patients with T-prolymphocytic leukemia (T-PLL) according to WHO criteria or pretreated patients (max. one previous treatment) with T-PLL * Age ≥ 18 years * WHO performance status of 0-2 * Life expectancy \> 6 months * CIRS score \>= 6 * Left ventricular ejection fraction ≥50% confirmed by echo-cardiogram performed \< 6 months before inclusion to the trial and after the end of a possible anthracycline containing pretreatment * Adequate liver function as indicated by a total bilirubin, AST and ALT \>= 2 the institutional ULN value, unless directly attributable to the T-PLL * Creatinine clearance \>= 70 ml/min calculated according to the formula of Cockcroft and Gault * Seronegativity for HIV, HBV or HCV confirmed by serological testing within 6 weeks prior to registration * Willingness of fertile male and female patients to use a highly effective contraceptive method with a Pearl-Index \< 1 during and at least six months after the end of the study treatment (e.g. implants, injectables, oral contraceptives in combination with another contraceptive method, some IUDs, sexual abstinence or vasectomised partner) * Negative serum pregnancy test one week prior to treatment (required for female patients before and \<2 years after onset of menopause) * Patient's written informed consent Exclusion Criteria: * Clinically significant auto-immune cytopenia or clinically significant hemolytic anaemia with suspicion of immune origin, even if Coombs test is negative * Active secondary malignancy requiring treatment (except basal cell carcinoma or tumour curatively treated by surgery) * Medical condition requiring prolonged use of oral corticosteroids (\> 1 month) * Cerebral dysfunction, legal incapacity * Any circumstance at the time of study entry that would preclude completion of the study and required follow-up * Active infection or severe infection (WHO 4th degree) within the last three months before inclusion to the study * Participation in any other clinical trial during this study * Known hypersensitivity to any of the study medications (Fludarabine, Cyclophosphamide, Mitoxantrone or Alemtuzumab) * Patients who have already received more than 60% of the recommended maximum cumulative dose of an anthracycline (Epirubicine, Adriamycine or Mitoxantrone). This maximum cumulative dose is defined for the individual substances as follows: * Epirubicin 900 mg/m² * Daunorubicin 550 mg/m², (or 400 mg/m² if the patient received mediastinal irradiation) * Adriamycine (Doxorubicine) 550 mg/m² * Mitoxantrone 200 mg/m² * Patients who already received Fludarabine in combination with Cyclophosphamide or Mitoxantrone * Patients who received prior treatment with Alemtuzumab alone or in combination with a purine analogue and who did not achieve a PR that lasted at least 6 months * Patients who are employees of the Sponsor (University of Cologne) or the study sites.