Efficacy and Safety Study of LE-DT to Treat Locally Advanced or Metastatic Pancreatic Cancer

Inclusion Criteria: 1. Patient is 18 years or older, male and female. 2. Patient has histopathologically confirmed diagnosis of adenocarcinoma of the pancreas. Patients with islet cell neoplasms are excluded. Biopsy sample must be available for SPARC assay. 3. Patients must have clinical or radiographic evidence of locally advanced or metastatic pancreatic cancer with measurable disease. 4. Male or non-pregnant and non-lactating female: * If a female patient is of child-bearing potential, as evidenced by regular menstrual periods, she must have a negative serum pregnancy test (β hCG) documented within 72 hours of the first administration of study drug. * If sexually active, the patient must agree to use contraception considered adequate and appropriate by the Investigator. 5. Patient can be newly-diagnosed without prior treatment or have failed initial adjuvant treatment with either gemcitabine, 5-FU or capecitabine with or without radiation therapy. 6. Patient has the following blood counts at baseline: * ANC greater than or equal to 1500 per uL * Platelets greater than or equal to 100000 per uL * Hgb greater than or equal to 9 g per dL 7. Patient has the following blood chemistry levels at baseline: * AST (SGOT), ALT (SGPT) less than or equal to 2.5 times of the upper limit of normal range (ULN), unless liver metastases are present, then less than or equal 5 times of the ULN is allowed * Bilirubin less than or equal to 1.5 times of the ULN * Serum creatinine less than or equal to 1.5 times of the ULN or calculated clearance greater than or equal to 60 mL/min for patients with serum creatinine levels above the institutional normal value. 8. Patient has acceptable coagulation profile as indicated by a Prothrombin time (PT) and Partial Thromboplastin Time (PTT) within normal limits (plus or minus 15%) unless explained by the use of anticoagulants 9. Patient has an Eastern Cooperative Oncology Group (ECOG) performance status 0-2 10. Patient has one or more metastatic lesions or locally advanced primary tumor measurable by CT or MRI. 11. Patient or legal representative must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board-approved written informed consent form prior to receiving any study related procedure. Exclusion Criteria: 1. Patient has known brain metastases. 2. Patient has active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy. 3. Patient has known infection with HIV, hepatitis B, or hepatitis C. 4. Patient has undergone major surgery, other than diagnostic surgery (i.e. surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to Day 1 of treatment in this study. 5. Patient who have received any other treatment for pancreatic cancer including radiotherapy, chemotherapy or any investigational therapy with the exception of initial adjuvant treatment including either gemcitabine, 5-FU or capecitabine with or without radiation therapy 6. Patient has a history of allergy or hypersensitivity to the study drug. 7. Patient has serious medical risk factors involving any of the major organ systems such that the Investigator considers it unsafe for the patient to receive an experimental research drug. 8. Patient has pre-existing peripheral neuropathy of Grade \>1 based on the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) 9. Patient is unwilling or unable to comply with study procedures. 10. Patient is enrolled in any other clinical or investigational trial.