Post Stroke Psychological Distress

Charite University, Berlin, Germany84 enrolled

Overview

Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.

The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Stroke

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Stroke in MCA/AchA territory of striato-capsular (at least 125mm³) or non-striatal (10-100cm³) involvement * MR-imaging can be conducted 24-48 hours of onset * preserved communication skills Exclusion Criteria: * Patients with psychiatric conditions or medication in the last 4 weeks * severe medical conditions * limited prognosis

Locations (1)

Charité, Campus Benjamin Franklin, Dep. of Neurology

Berlin, State of Berlin, Germany

Outcomes

Primary Outcomes

occurence of depression (GDS, SKID)

Geriatric Depression Scale, Structured Clinical interview for DSM-IV

Time frame: 90 days

Secondary Outcomes

change in saliva cortisol

measurement of saliva cortisol levels

Time frame: 90days

change in serumcholine

measurement of serumcholine

Time frame: 90days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.