The purpose of this study is to compare the effectiveness of three analgesia techniques on pain relief and functional recovery after knee replacement: continuous femoral nerve block vs single-injection femoral nerve block with intravenous patient controlled analgesia vs intravenous patient controlled analgesia.
Primary Outcome Measures: * Incidence of patients with significant pain on movement on day 1 post surgery * Range of knee flexion Secondary Outcome Measures: * Pain intensity (rest/movement) * Functional recovery * Knee Injury and Osteoarthritis Score * Side effects/ Adverse outcomes * SF12 Quality of Life Questionnaire * Length of stay
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
200
20mls of 0.25% Bupivacaine with 1/400,000 adrenaline (2.5mcg/ml) If catheter localized to \< 1.0mA, 0.1mS with patella twitch, start Bupivacaine 0.125% 4ml/hr. If unable to get twitch through catheter in final location or twitch at current ≥ 1.0m/A, start Bupivacaine 0.125% 6ml/hr.
Tan Tock Seng Hospital
Singapore, Singapore
Incidence of patients with significant pain on movement on day 1 post surgery
Time frame: Post op day 1
Functional recovery
Time frame: During hospitalization, week 2, week 12
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