Evaluation of Delirium Prevention in Critically Ill Patients

Radboud University Medical Center650 enrolled

Overview

Haloperidol is prescribed in high risk ICU patients concerning delirium (50% or more chance to develop delirium detected with the delirium prediction model PRE-DELIRIC, or patients with history of dementia or alcohol abuse)since the delirium protocol is changed and haloperidol is added as a prevention treatment we are gathering information what the effect is on several aspects of delirium

Measurement the effect of haloperidol as delirium preventive intervention. Determining effect on: \- delirium incidence in the ICU - different subtypes of delirium - delirium free days in 28 days - days on the ventilator - length of stay on the ICU and In-Hospital - 28-day mortality - incidence of unexpected removal of tubes, and effect between different groups of patients. Safety of haloperidol concerning QT-time, extrapyramidal symptoms. Data are compared with the data of a historical cohort

Study Type

OBSERVATIONAL

Enrollment

650

Conditions

Delirium

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients With Predicted Delirium Chance of \>50% or history of dementia or alcohol abuse and treated with haloperidol Exclusion Criteria: * CAM-ICU is Not Applicable * Patients Admitted 24hours or Shorter on the ICU, Patients Who Are Delirious Within 24 Hours After ICU Admission * patients whereby haloperidol is contra-indicated

Locations (1)

Radboud University Nijmegen Medical Centre

Nijmegen, Netherlands

Outcomes

Primary Outcomes

Delirium incidence

Delirium is diagnosed as minimal one positive CAM-ICU screening during complete ICU admission. Incidence rate is compared with historical cohort data

Time frame: one year

Secondary Outcomes

duration of delirium days on mechanical ventilator Length of stay in the ICU and in-hospital in-hospital mortality incidence of unplanned removal of tube incidence of delirium subtypes

measured prospectively and determined in a CRF and compared with historical cohort data

Time frame: one year

Effect haloperidol on biomarkers

Biomarkers are measured in patients with high risk for delirium which are preventively treated with haloperidol

Time frame: one year

Data from ClinicalTrials.gov

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