The aim of this study is to compare the effects of Adaptive Servo Ventilation (Bipap® auto SV Advanced) and oxygen therapy in chronic heart failure patients complicated with central sleep apnea.
Central sleep apnea(CSA) is associated with chronic heart failure(CHF). At present, both of nocturnal oxygen therapy and adaptive servo ventilation(ASV) are recognized as effective modalities. However,in fact, majority of CHF patients are complicated not only with CSA but with obstructive sleep apnea(OSA). Recently, Philips developed Bipap® auto SV Advanced for such patients. It has auto-CPAP function as the modality of OSAS, in addition to ASV function. The present study is prospective randomised study to compare the effects of nocturnal oxygen therapy and Bipap® auto SV Advanced.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
43
Nocturnal use of Adaptive servo ventilation
Nocturnal use of oxygen
Kyoto University Hospital
Kyoto, Kyoto, Japan
Left ventricular ejection fraction confirmed by echocardiography
Time frame: three months
Sleep quality confirmed by polysomnography
Time frame: three months
Endothelial function
Time frame: three months
Sleepiness
Time frame: three months
Blood pressure
Time frame: three months
Serum biomarkers
Inflammation, oxidative stress
Time frame: three months
health-related quality of life
Time frame: three months
Urinary biomarkers
inflammation, oxidative stress
Time frame: three months
Heart rate
Time frame: three months
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