Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes

Inclusion Criteria: * Signed informed consent * Male aged between 18 and 45 years * No clinically significant findings on the physical examination * Body mass index (BMI) between 18 and 28 kg/m2 * Systolic blood pressure (SBP) 100-145 mmHg, diastolic blood pressure (DBP) 50-90 mmHg, and heart rate (HR) 45-90 bpm (inclusive) * 12-lead electrocardiogram (ECG) without clinically relevant abnormalities * Hematology and clinical chemistry results not deviating from the normal range to a clinically relevant extent * Negative results from urine drug screen * Ability to communicate well with the investigator and to understand and comply with the requirements of the study Exclusion Criteria: * Known hypersensitivity to any excipients of the drug formulations * Treatment with another investigational drug within 30 days prior to screening * History or clinical evidence of alcoholism or drug abuse within the 3-year period prior to screening * Excessive caffeine consumption, defined as mor than 800 mg per day * History or clinical evidence of any disease and/or existence of any surgical or medical condition, which might interfere with the absorption, distribution, metabolism or excretion of the study drug * Smoking within the last 3 months prior to screening * Previous treatment with any prescribed or OTC medications (including herbal medicines such as St John's Wort) within 2 weeks prior to screening * Loss of 250 ml or more of blood within 3 months prior to screening * Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol * Legal incapacity or limited legal capacity at screening