Effects of Dietary Fructose Reduction in Children With Hepatic Steatosis

Overview

Primary Objectives: 1. To determine whether a 4 week reduction in dietary fructose intake improves hepatic steatosis in overweight children who have a baseline high fructose consumption and hepatic steatosis. 2. To determine if a 4 week reduction of dietary fructose improves fasting plasma triglycerides, free fatty acids, very low-density lipoprotein, insulin and glucose as well as post-prandial levels in response to a high fructose meal. 3. To determine if a 4 week reduction of dietary fructose improves markers of oxidative stress. Study Design: A blinded randomized study comparing glucose beverages to isocaloric fructose beverages administered over 4 weeks.

Planned Sample Size: Phase 1) 96 subjects Phase 2) 40 subjects Patient Population: Overweight Hispanic children with non-alcoholic fatty-liver disease age 11 to 18 years who are stable and not taking any chronic medication with no recent acute illnesses. Definitions: * BMI \>95th %tile for age and gender * Self-identified as Hispanic/Latino * Baseline hepatic fat fraction \> 10% (Have nonalcoholic fatty liver disease) * Sweetened beverage intake of at least 24 ounces/day

Conditions

Interventions