The objectives of the proposed study are to assess the effect of walnut consumption on parameters of lipid metabolism, glucose metabolism, incretins and adipokines, endothelial function and blood pressure in healthy men and healthy postmenopausal women
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
walnut consumption 48 g/d
Med Dept. 2 Grosshadern
Munich, Germany
Fasting non-HDL-cholesterol
Time frame: 8 weeks
area under the triglyceride curve (AUC-TG)
area under the plasma triglyceride concentration curve following a standardized oral fat challenge
Time frame: 8 weeks
incremental area under the triglyceride curve (iAUC-TG)
incremental area under the plasma triglyceride concentration curve following a standardized oral fat challenge
Time frame: 8 weeks
LDL-cholesterol
fasting plasma LDL-cholesterol concentration
Time frame: 8 weeks
HDL-cholesterol
fasting plasma HDL-cholesterol concentration
Time frame: 8 weeks
triglyceride
fasting plasma triglyceride concentration
Time frame: 8 weeks
glucose
fasting plasma glucose concentration
Time frame: 8 weeks
HOMA
Time frame: 8 weeks
insulin
Time frame: 8 weeks
HbA1c
Time frame: 8 weeks
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area under the glucose curve (AUC-glucose)
area under the plasma glucose concentration curve following a standardized oral challenge
Time frame: 8 weeks
area under the insulin curve (AUC-insulin)
area under the plasma insulin concentration curve following a standardized oral challenge
Time frame: 8 weeks
endothelial function
Postprandial (mixed meal challenge) endothelial function (flow mediated dilatation, flow-independent dilatation)
Time frame: 8 weeks