Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery

Gangnam Severance Hospital84 enrolled

Overview

The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Hyperalgesia

Interventions

propofol, sevofluraneDRUG

Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min (group1 and 2) group 1 (Active Comparator, sevoflurane)will be infused propofol intraoperatively. group 2(Experimental, propofol) will be inhaled sevoflurane intraoperatively.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing thyroidectomy * Age 20-65 * American Society of Anesthesiologists physical status classification I or II Exclusion Criteria: * History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs * History of drug \& alcohol abuse * Psychiatric disorder * Use of opioids within 24hrs * Renal disease with decreased glomerular filtrate ratio * Neuromuscular disease, Severe cardiac disease

Locations (1)

Gang Nam Severance Hospital, Yonsei University, Anesthesia and Pain Medicine Department,

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs

Time frame: postoperative 48 hrs

Central Contacts

young ju won, MD.

CONTACT

082-2-2019-6805 moma2@naver.com

yuen hee shim, MD.

CONTACT

082-2-2019-6808 tren125@yuhs.ac

Data from ClinicalTrials.gov

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