The purpose of this study is to determine whether taking grape seed extract prior to eating a high fat meal will reduce the inflammatory response in people with the metabolic syndrome.
The purpose of this study is to determine whether taking grape seed extract prior to eating a high fat meal will reduce the inflammatory response in people with the metabolic syndrome. If this extract is shown to mitigate the inflammatory response induced by a high fat meal, it could potentially aid in postponing of the diagnosis of diabetes or other chronic diseases associated with high levels of inflammation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
12
Sugar pill containing maltodextrin.
Meganatural Gold® contains 300mg of grape seed extract.
University of California Davis (Academic Surge, Ragle Human Nutrition Research Facility)
Davis, California, United States
VA Hospital, Mather
Mather, California, United States
Modification of the postprandial inflammatory response.
Analysis of inflammatory markers known to increase following a meal high in fat (\~40% kcal from fat). Markers to be analyzed will include the following: 1. Serum lipids 2. Oxidized LDL 3. Hs-CRP 4. TNFα 5. IL1 6. IL6
Time frame: 7 hours
Metabolic response to a high fat meal.
Assay for the insulin and glucose response generated from consumming a high fat meal (\~40% of kcal from fat).
Time frame: 7 hours
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