Pilot Study of Maintenance Therapy With Intravenous AMANTADINE

N/AUnknownNCT01190553

Rabin Medical Center20 enrolled

Overview

This is a pilot study for Maintenance Intravenous Treatment with AMANTADINE in patient with PARKINSON'S Disease who are not well balanced with medical treatment.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Parkinson Disease

Interventions

AmantadineDRUG

Initiation: IV amantadine 200mg/500ml \* 1/d for 3 days Maintenance: IV amantadine 200mg/500ml once per 6 weeks for 6 months

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with idiopathic Parkinson disease * Age\<80 * Patients with no motor improvement under optimal treatment with anti parkinson medications * Patients with moderate to severe dyskinesias * Patients with PD with side effects who can not tolerate anti parkinson medications Exclusion Criteria: * Age\>80 * Patients with Parkinson syndromes, vascular parkinsonism or drug-induced parkinsonism * Patients with PD who developed adverse reactions to oral amantadine * Contraindication of amantadine treatment

Outcomes

Primary Outcomes

Improvement of UPDRS scores after 6 months of treatment

Time frame: 6 months

Improvement of dyskinesias score.

Time frame: 6 months

Data from ClinicalTrials.gov

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