The purpose of this study is: To validate the efficacy of multiparametric MRI, FDG-PET, RGD-PET, and PET-MR fusion imaging in the prediction and monitoring response to neoadjuvant chemotherapy of locally advanced breast cancer patients. To identify the optimal combination parameters of MR spectroscopy, diffusion-weighted MRI, dynamic contrast-enhanced MRI, FDG-PET, and RGD-PET in the prediction and monitoring response to neoadjuvant chemotherapy of locally advanced breast cancer patients. To compare the performances of dynamic contrast-enhanced MRI using parametric response map analysis versus those of pharmacokinetic parameters (Ktrans, kep, or Ve) in the early prediction of pathological responsiveness to neoadjuvant chemotherapy in breast cancer patients
Enrolled women with breast cancers who had received an anthracycline-taxane regimen and subsequent surgery were prospectively enrolled. DCE-MRI and FDG-PET scan were performed before and after the 1st cycle of chemotherapy. MR imaging parameters and SUV on PET scan within a tumor were analyzed. Clinicopathologic (age, clinical tumor stage, hormonal receptor status, and surgery type) and imaging parameters were compared according to the pathological response.
Study Type
OBSERVATIONAL
Enrollment
57
Seoul National University Hospital
Seoul, South Korea
Patholocial Response to Chemotherapy
Pathological complete response (pCR) or non-pCR
Time frame: Post-operation
Tumor Size
Maximal tumor diameter measured on magnetic resonance imaging
Time frame: baseline, completion of 1st cycle of chemotherapy
Tumor Volume
Tumor volume measured on 3-dimensional magnetic resonance imaging
Time frame: Baseline, post-1st chemotherapy
Proportions of Voxels Within a Tumor With Increased or Decreased Signal Intensity (Parametric Response Map Signal Intensity; PRMSI)
Parametric response map analysis using a software calculates the interval change of signal intensity based on a voxel-to-voxel comparison between measurements at baseline and after the first cycle of chemotherapy. PRMSI+ indicates proportions of voxels within a tumor with increased signal intensity. PRMSI- indicates proportions of voxels within a tumor with decreased signal intensity. PRMSI0 indicates proportions of voxels within a tumor with unchanged signal intensity.
Time frame: Baseline, post-1st chemotherapy
Constant for the Transfer of the Contrast Agent From the Plasma Compartment Into the Extracellular Extravascular Space (Ktrans)
Time frame: Baseline, post-1st chemotherapy
Rate Constant of the Escape of the Contrast Agent From the Extracellular Extravascular Space Into the Plasma Compartment (Kep)
Time frame: Baseline, post-1st chemotherapy
Extracellular Extravascular Space Per Unit Volume of Tissue (Ve)
Time frame: Baseline, post-1st chemotherapy
Total Choline Amount of the Tumor Measured on Single Voxel 1H-magnetic Resonance Spectroscopy
Single voxel 1H-magnetic resonance spectroscopy quantifies the amount of total choline-containing compounds of a tumor, which indicates cellular proliferation and malignant transformation.
Time frame: Baseline, post-1st chemotherapy
Standardized Uptake Value on 18F-fluoro-deoxy-glucose Positron Emission Tomography
Time frame: Baseline, post-1st chemotherapy
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