A Study to Evaluate the Drug Interaction of ASP015K and Tacrolimus

Inclusion Criteria: * Subject weighing at least 45kg and body mass index (BMI) of 18-32 kg/m2, inclusive * If female, subject is at least 2 years post menopausal or is surgically sterile per documentation provided by a third party medical professional and the subject is not pregnant as documented by a negative serum pregnancy test * If male, subject agrees to sexual abstinence, is surgically sterile, or is using a medically acceptable method to prevent pregnancy during the study period * 12-lead ECG is normal or if abnormal, the abnormality is not clinically significant * Clinical laboratory test results are within normal limits or not clinically significant * Medically healthy, with no clinically significant medical history or abnormalities Exclusion Criteria: * History of any clinically significant disorder, disease or malignancy excluding non-melanoma skin cancer * Recent history (within 6 months) of drug or alcohol abuse or positive urine screen for drugs of abuse/illegal drugs * Treatment with prescription drugs or complementary and alternative medicines (CAM) within 14 days prior to study drug administration, or over the counter medication within 1 week prior to study drug administration * A symptomatic, viral, bacterial or fungal infection within 1 week prior to clinic check-in * Positive test for hepatitis C antibody, or positive test for hepatitis B surface antigen (HBsAg) * History of human immunodeficiency virus (HIV) antibody * Positive tuberculosis (TB) skin test or Quantiferon Gold test * Vaccinated within the last 30 days prior to study drug administration * Received an experimental agent within 30 days or five half-lives, whichever is longer, prior to study drug administration * Any significant blood loss, donated one unit (450 mL) of blood or more, or received a transfusion of any blood or blood products within 60 days or donated plasma within 7 days prior to clinic admission * Absolute neutrophil count (ANC) \<2500 cells/mm3