Safety, Tolerability and Clinical Activity of ASM-024 in Stable Moderate Asthma

Inclusion Criteria: * Able and willing to provide written informed consent. * Male or female subjects, ≥ 18 years and ≤ 55 years of age * Diagnosis of moderate asthma and on regular inhaled corticosteroids with or without short or long-acting Beta-2-agonists * FEV1 ≥ 55 % predicted in the absence of medications for asthma * Female subjects of childbearing potential must have a negative pregnancy test (serum beta-human chorionic gonadotropin (b-HCG)) at Screening, and a negative pregnancy test immediately before the administration of the study drug for each of Periods 1, 2 and 3. Sexually active females with non-sterile partner must be willing to use adequate contraception. * Male subjects must be willing to use a condom with a spermicide for the duration of their participation in the study, plus an additional 30 days following study drug administration and ensure that their partner is using a highly effective method of birth control such as combined oral contraceptives, implants, injectables or an intra-uterine device (IUD). Male subjects must ensure that their female partner is willing to use adequate contraception. * Demonstration of an increase in FEV1 by ≥ 10 % predicted between spirometry performed before and 10-20 minutes after the administration of 2 puffs of 100 micrograms of salbutamol at Screening. Exclusion Criteria: * Clinically significant conditions or illnesses other than moderate asthma or systemic diseases * Pregnant or nursing women or women intending to conceive during the course of the study or have a positive serum pregnancy test at Screening or a positive urine pregnancy test during the study. * Women of childbearing potential (unless surgically sterilized by hysterectomy or bilateral tubal ligation, or post-menopausal for at least two years) not using a highly effective method of birth control. * Non-surgically sterile males and males with partners of childbearing potential not willing to use a condom with spermicide for the duration of their participation in the study plus an additional 30 days following study drug administration and to ensure that their partner is using a highly effective method of birth control such as combined oral contraceptives, implants, injectables or an IUD. * Respiratory tract infections or worsening of asthma or changes in asthma medications within 6 weeks before Screening/Baseline. * Current cigarette smokers or former smokers with a smoking history of greater than 10 pack years or who stopped smoking within 12 months preceding enrolment in the study. * Positive urine cotinine test at Screening. * History of illicit drug use or alcohol abuse within 12 months before Screening. * Positive test for Hepatitis B, Hepatitis C or Human Immunodeficiency Virus (HIV) at Screening. * Any medication that are known to prolong QT / QTc interval. * Any of the following concomitant medications preceding the administration of salbutamol during Screening and preceding the administration of the study drug: * Oral or i.v. corticosteroids within 1 month; * Inhaled or intranasal corticosteroids within 48 hours; * Long acting Beta-2-agonists within 24 hours; * Short acting Beta-2-agonists within 8 hours; * Anticholinergic aerosols within 24 hours; and * Theophylline-containing products within 48 hours. * Use of NSAIDs within 7 days preceding the administration of salbutamol during Screening and throughout the study. * Use of antihistaminic drugs within 3 days preceding the administration of salbutamol during Screening. * Use of an investigational product or participation in a clinical trial using an investigational product within 30 days before dosing or within 90 days in the case of long-acting products (ex.: Depo-medrol) or biologics with a long-acting half-life (ex.: monoclonal antibodies).