Monitoring Exhaled Propofol to Individualize General Anesthesia

Phase 1CompletedNCT01191021

University of California, San Francisco20 enrolled

Overview

This trial investigates the relationship between concentrations of the anesthetic drug propofol in exhaled breath, blood and drug effect in volunteers undergoing general anesthesia. The main goal of this study is to develop a pharmacokinetic - and dynamic model for propofol in exhaled breath.

Study Type

INTERVENTIONAL

Allocation

Masking

SINGLE

Enrollment

Conditions

General Anesthesia

Interventions

Propofol AnesthesiaDRUG

Volunteers will undergo propofol anesthesia for 90 min.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age * Written informed consent * Ability and willingness to give written informed consent * American Society of Anesthesiologists (ASA) risk score I Exclusion Criteria: * Volunteers ASA physical status II - III * Pregnancy * Volunteers with history of neurological disease or stroke * Volunteers with a history of recreational drug abuse * Volunteers with a history of alcohol abuse * Smokers * Anesthesia within 6 months * Known drug allergies * History of adverse events during general anesthesia

Locations (1)

Department of Anesthesia and Perioperative Care, UCSF

San Francisco, California, United States

Outcomes

Primary Outcomes

Exhaled propofol (parts per billion)

Time frame: Continuous measurement over 90 min

Processed electroencephalography (Bispectral Index (0-100)): Change from baseline during anesthesia

Time frame: continuous over 90 min

Data from ClinicalTrials.gov

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