Leucine Supplementation and Skeletal Muscle Disuse

N/ACompletedNCT01192009

University of Sao Paulo22 enrolled

Overview

Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Disuse Atrophy

Interventions

LeucineDIETARY_SUPPLEMENT

7.2 g of leucine during 2 weeks

PlaceboDIETARY_SUPPLEMENT

7.2 g of alanine during 2 weeks

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of anterior cruciate ligament injury * Physically active * Must be able to swallow tablets * Non-smokers * Do not use nutritional supplements Exclusion Criteria: * Post-surgical complications

Locations (1)

University of São Paulo - School of Physical Education and Sports

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Skeletal muscle structure (cross-sectional area)

Time frame: 2 weeks

Secondary Outcomes

Molecular signalling pathways (hypertrophy, atrophy, and inflammation)

Time frame: 2 weeks

Data from ClinicalTrials.gov

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