A large project consisting of: a) an observational trial where smoking status is recorded on 1400 consecutive people newly diagnosed with lung cancer. Smoking status is biologically validated with exhaled carbon monoxide (eCO) levels every 3 months. Survival, cancer progression and treatment complications will be recorded and compared in smokers, ex-smokers and never smokers.
Smoking causes around 85% of lung cancer. Continued smoking after diagnosis probably worsens survival and increases treatment complications but prospective well-designed studies are lacking. This project is an observational cohort study recording outcomes in smokers, never-smokers, and ex-smokers, using exhaled carbon monoxide to validate smoking status when they attend for further lung cancer clinics. This project is unique, as every patient with a clinical diagnosis of lung cancer will have their smoking status biologically validated by a quick and easy test, and those enrolled in the smoking cessation treatments or not will also complete a generic quality of life questionnaire at regular intervals. These appointments will coincide with other hospital appointments wherever possible, and survival status will reported up to 24 months after enrolment.
Study Type
OBSERVATIONAL
Enrollment
2,400
Llandough Hospital, Cardiff and Vale University Health Board
Cardiff, Wales, United Kingdom
Hywel Dda Health Board
Llanelli, Wales, United Kingdom
Median and 2-year survival rates in confirmed smokers versus non- smokers newly diagnosed with lung cancer.
Time frame: 24 months
Median survival and 2-year survival rates by smoking status for early (Stage I/II NSCLC) versus those with advanced (Stage III/IV) NSCLC.
Time frame: 24 months
Number of treatment complications in smokers versus non-smokers (frequency surgical wound complications, radiotherapy induced pneumonitis and median total radiation (Gy) dose; frequency and duration of neutropenic sepses
Time frame: 2 years
Point prevalence of smoking at 0, 3, 6 12, 24 months
Time frame: 2 years
Comparison of changes in health related quality of life (EQ5D) in smokers versus non-smokers
Time frame: 2 years
Accrual and attendance rates of lung cancer patients attending a hospital smoking cessation service
Time frame: 2 years
Estimate of cost per quality adjusted life year gained by smoking cessation advice in both quit strategies for smokers
Time frame: 2 years
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