A Multiple Ascending Dose Study of GS 5885 in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C

Inclusion Criteria: * Chronically infected with HCV genotype 1 * HCV treatment-naïve * Not co-infected with HIV or HBV * HCV RNA viral load of at least 100,000 IU/mL * BMI 19 to 35 kg/m2 * Subject agrees to use highly effective contraception methods if female of childbearing potential or sexually active male. Exclusion Criteria: * History of clinically-significant illness or any other major medical disorder that may interfere with subject treatment, assessment or compliance with the protocol * Decompensated liver disease or cirrhosis or evidence of hepatocellular carcinoma * Serological evidence of co-infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV), or another HCV genotype * Subjects with known, current use of amphetamines and/or cocaine; subjects taking methadone or buprenorphine (opioid replacement therapy) or ongoing alcohol abuse