Preliminary studies in rats and mice indicate that calanus oil reduce accumulation of intra-abdominal fat. Pilot studies in humans have shown no adverse effects. In the present study 120 subjects, males and females, 20-65 years old, BMI 25-30 kg/m2 will be included and given calanus oli 1 g twice daily versus placebo for 1 year. The hypothesis is that calanus oil will reduce intra-abdominal fat, improve glucose tolerance and lipid profile.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
117
1 gram twice daily
1 gram twice daily
University of Tromso
Tromsø, Norway
Intra-abdominal fat as measured with CT scan
Time frame: at the end of 12 months intervention
oral glucose tolerance test
Time frame: at the end of 12 months intervention
lipid status
Time frame: at the end of 12 months intervention
systolic and diastolic blood pressure
Time frame: at the end of 12 months intervention
markers of inflammation - C-reactive protein (CRP)
Time frame: at the end of 12 months intervention
body weight
Time frame: at the end of 12 months intervention
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