Scoring System for Inhalation Injury

N/ACompletedNCT01194024

American Burn Association108 enrolled

Overview

The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy

Study Type

OBSERVATIONAL

Enrollment

108

Conditions

Inhalation Injury

Interventions

Standard of CareOTHER

bronchoscopy with collection of bronchioalveolar lavage specimen, blood samples, High-Resolution spiral computed tomography(CT)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Injury consistent with inhalation of smoke or products of combustion * Requires intubation within 24 hours of injury * Meets one of the following 4 criteria 1. history of closed space injury 2. carbonaceous sputum 3. elevated carboxyhemoglobin 4. dx of inhalation injury is considered likely by investigator Exclusion Criteria: * ≤ 17 years of age * Prisoner

Locations (9)

The Arizona Burn Center, Maricopa Integrated Health Systems

Phoenix, Arizona, United States

Arkensas Children's Hopital

Little Rock, Arkansas, United States

University of California Davis Medical Center

Sacramento, California, United States

Outcomes

Primary Outcomes

Development of a diagnostic model to predict the severity of inhalation injury

The development of a diagnostic model to predict the severity of inhalation injury based on demographics, characteristics of injury, bronchoscopy, CT scan, and inflammatory markers.

Time frame: within 48 hours of admission

Secondary Outcomes

Impact of inhalation injury

Assessment of the impact of inhalation injury on the incidence of pneumonia, acute respiratory distress syndrome (ARDS), and acute lung injury (ALI).

Time frame: at discharge

Data from ClinicalTrials.gov

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