Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance

Inclusion Criteria: * All healthy men and women 18 to 39 years of age are eligible to participate. Exclusion Criteria: Must be able to swallow whole pills. * Self-reported habitual nightly sleep amounts outside the target range of 6-8 hours (i.e., less than 6 hours per night or more than 8 hours per night, on average) * Cardiovascular disease (to include but not limited to arrhythmias, valvular heart disease, congestive heart failure, family history of sudden cardiac death or myocardial infarction) as determined by participant self report. * Current hypertension or high blood pressure (greater than 140/90) * Neurologic disorder (to include but not limited to epilepsy or another seizure disorder, amnesia for any reason, hydrocephalus, MS, narcolepsy or other sleep disorders) * Kidney disease * History of psychiatric disorder requiring hospitalization or psychiatric medication for any length of time * Beck Depression Inventory score of 14 or above * Underlying pulmonary disease requiring daily inhaler use * Regular nicotine use (or addiction) (defined as more than 1 cigarette or equivalent per week) within the last 3 years * Heavy alcohol use (more than 2 drinks per day; http://www.cdc.gov/alcohol/faqs.htm#10) * Use of other illicit drugs (to include but not limited to benzodiazepines, amphetamines, cocaine, marijuana) * Known liver disease or liver abnormalities as determined by a laboratory test * Known ulcer disease or risk of ulcer disease (stomach bleeding) * Self-reported history of caffeine use in excess of 400 mg (8 caffeinated sodas or 3-4 cups, each \~ 6 oz, of coffee) per day on average * Pregnancy (females) * Breast-feeding (females) * Prior anaphylactic reaction, angioedema, or other severe psychological reactions to any of the test compounds