Lendexal in Patients With Primary Systemic Amyloidosis (AL) Newly Diagnosed

Inclusion Criteria: * Understand and voluntarily sign an informed consent form. * Age \> 18 years at the time of signing the informed consent form. * Able to adhere to the study visit schedule and other protocol requirements according with investigator criteria. * Diagnosis of symptomatic primary systemic amyloidosis based on tissue Congo red positive staining as well as positive immunohistochemical staining for light chains or presence of a monoclonal protein in serum and/or urine or clonal bone marrow plasma cells * Previously untreated disease * Patients should not candidates for up-front high-dose therapy/stem cell transplantation * Serologically measurable disease defined as follows: Evidence of a monoclonal light chain in serum and urine by immunofixation Raise of the level of circulating free light chains above the ordinary limits and an abnormal relationship kappa/lambda. * Performance status ECOG ≤ 2 (see Annex 3). * Laboratory tests results within these ranges: Absolute neutrophil count ≥ 1 x 10 9/ L. Platelet count ≥ 100 x 10 9/ L Serum creatinine less than 3.0 mg/dL Serum bilirubin less than 3.0 mg/dL \- Females of childbearing potential (FCBP) must agree to: Know the teratogenic risks of the study drug Commit to use contraceptives during the 4 weeks before the start of this study drug treatment, during the treatment and also 4 weeks after it, even amenorrheic cases. All of it applies always except women committed to maintain sexual abstinence confirming it monthly. Some of effective contraceptives are: Birth control implant Levonorgestrel-releasing intrauterine device. Depot medroxyprogesterone acetate Tubal ligation Sexual intercourse only with a vasectomized partner. The effectiveness of vasectomy must be confirmed by two semen analysis; the result must be negative Inhibiting ovulation pill progesterone only (for example: desogestrel) if it is determined that the patient doesn't use an effective contraceptive method will be referred to a skilled health professional to receive advice on contraception, so that they can begin to birth control measures. It's discouraged combine oral contraceptives in myeloma multiple women cases treated with Lenalidomide combined with Dexamethasone due to high venous thromboembolism risk. In case these kind of patient were having combined oral contraceptives, she must change to another one of list above. Risks of venous thromboembolism will remain during the 3 or 4 weeks after discontinue combine oral contraceptives treatment. Concomitant treatment with dexamethasone reduces the effectiveness of contraceptive steroids. Implants and levonorgestrel-releasing intrauterine systems are related to higher risks of infections at the moment of the implant or when there is metrorrhagia. It should be considered prophylactic treatment with antibiotics for neutropenic patients. Normally it's discouraged copper intrauterine devices because of the infection risk and menstrual blood loss at the moment of the implant for patients with neutropenia or thrombocytopenia. Women patients must follow all warnings for an effective contraception, even if she is amenorrheic. Women patients must be aware about effects of pregnancy and go to a health care centre urgently in case of pregnancy risk. She must take a pregnancy test with a minimum sensitivity of 25 mUl/ml, under medical supervision, when the study visits or three days before the visit, when she were 4 weeks at least using effective contraceptive methods. This requirement applies for women who practice a complete and continuous sexual abstinence. Test should confirm that the patient is not pregnant at the time of starting treatment. She must take a pregnancy test, under medical supervision, each 4 weeks, even a pregnancy test 4 weeks after the end of the study treatment, except in case of a confirmed tubal ligation. Pregnancy test should be performed the day of the study's visit or during the three days before it. This requirement also applies for childbearing women who practice a complete and continuous sexual abstinence. \- Male patients must: Undertake to use latex condoms during treatment with study medication including all periods of interruption of doses, even one week after finishing treatment if his partner is a woman of childbearing who doesn't use contraceptive methods. Commit not to donate semen during treatment with study medication and even one week after finishing treatment. \- All patients should: Refrain from donating blood during treatment with study medication and even one week after finishing treatment. Refrain from sharing the study medication with other people and return unused study medication to the investigator or the pharmacist. Exclusion Criteria: * Localized cutaneous AL, only carpal tunnel syndrome, merely vascular amyloid in the bone marrow biopsy, AL in a plasmacytoma or AL associated to multiple myeloma (\>30% plasma cells in bone marrow, lytic bone lesions, hypercalcemia, plasmacytomas). * Other causes of amyloidosis (secondary, familial, senile). * Candidates for high dose chemotherapy/ stem cell transplant. * Previously treated AL. * Any condition including laboratory abnormalities, which placed the subjects at unacceptable risk if he/she were to participating the study or confounds the ability to interpret data from the study. * Use of any other experimental drug or therapy within 28 days prior to baseline. * Any prior use of lenalidomide * Any cancer in the previous 5 years, except no melanoma skin cancer, cervix or prostate cancer treated in the initial state with prostate-specific antigen within normal limits. * Known positive for HIV. * Cardiac ejection fraction below 50% * Pregnant or breast-feeding (can not breast-feed while taking lenalidomide) * Patients who are not able to use antithrombotic prophylaxis or reject.