Evaluation of Histamine H3 Receptor Radioligand [11C]AZ12807110 and Histamine H3 Receptor Occupancy of AZD5213 After Oral Administration

Inclusion Criteria: * Healthy male and/or female volunteers between 20 to 45 years with suitable veins for cannulation or repeated venipuncture (pilot panel) * Female must be of non-child bearing potential (pilot panel) * BMI between 18 to 30 30 kg/m2 * Normal MRI scan * Provision of signed, written and dated informed consent Exclusion Criteria: * History of any clinically significant disease or disorder * History or presence of gastrointestinal, hepatic or renal disease * Prolonged QTcF \>450 ms or shortened QTcF \<340 ms or family history of long QT syndrome * History of severe allergy or hypersensitivity or ongoing allergy or hypersensitivity * Healthy volunteer suffers from claustrophobia