The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study. An interim analysis will be performed when 100 patients will be included.
Secondary objectives of this clinical trial : * To evaluate the effect of COPD and/or OSAS on the systemic inflammation, insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients. * To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of the adipose tissue, in comparison with non COPD non OSAS patients. * To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery
Study Type
OBSERVATIONAL
Enrollment
109
University Hospital of Angers
Angers, France
Mutualist Hospital group
Grenoble, France
University Hospital of Grenoble
Grenoble, France
The primary endpoint is the percent of peripheral arterial tone (PAT) in COPD and/or OSAS patients compared to non COPD non OSAS patients.
Time frame: one week before their cardiovascular surgery
Evaluation of the systemic inflammation, insulin-resistance and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients.
Time frame: one week before their cardiovascular surgery
Evaluation of adipose tissue inflammation and oxidative stress occurring during COPD and/or OSAS patients compared to non COPD non OSAS patients.
Time frame: one week before their cardiovascular surgery
Polysomnography
Time frame: one week before their cardiovascular surgery
Functional respiratory exploration
Time frame: one week before their cardiovascular surgery
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