Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis

Phase 2CompletedNCT01198223

Qazvin University Of Medical Sciences40 enrolled

Overview

The aim of the present study was to compare the effect of aqueous extract of garlic with nystatin mouthwash in denture stomatitis.

Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Denture Stomatitis

Interventions

garlic , nystatinDRUG

mouthwash

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 40 years of age and older * confirm of denture stomatitis by the oral medicine specialists Exclusion Criteria: * Patients with a history of using anti-fungal drugs, antibiotics, and corticosteroid within the previous month * allergy to garlic and nystatin mouthwash * immunodeficiency * uncontrolled diabetes * those with garlic rich diet * inability in using mouthwash * loose and discolored dentures * psychologic disorder and alzheimer

Locations (1)

QUMS

Qazvin, Qazvin Province, Iran

Outcomes

Primary Outcomes

reduction of diameter of erythematous lesion under denture

measuring erythematous lesion by visual and then photography and a colis

Time frame: first week

Secondary Outcomes

complete relief of erythematous lesions

Time frame: fourth week

Data from ClinicalTrials.gov

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