Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension

Inclusion Criteria: * Adult subjects 20-50 years of age * Above 55Kg and within ±20% ideal body weight * Subjects who are in average of 130mmHg ≤ systolic blood pressure (SBP) \< 160mmHg, 80mmHg ≤ diastolic blood pressure (DBP) \< 100mmHg * Female subject who confirmed non-pregnant status and agree to comply with proper contraception. * Subjects who wrote informed consent Exclusion Criteria: * Subjects who are suspected to have acute disease * Subjects who have past history that may affect drug absorption, distribution, metabolism and elimination * Subjects who have gastrointestinal history * Subjects whose heartrate is less than 60 * Subject who suspected to orthostatic hypotension * Subjects who have clinically significant allergy disease * Subject is currently participating or has participating in a study with an investigational compound or device within 30 days of signing informed consent * Administration of prescription drug within 14 days or over the counter (OTC) drug within 7 days * Subjects who have past history of drug abuse and positive in drug screening test * Subjects who donate whole blood within 60 days and platelet within 30days. * Subjects taking St John's wort or CYP inhibitor and inducer