The objective of this study is to investigate the antidepressant efficacy of rTMS, and to assess cortical metabolism before and after rTMS sessions in patients with major depression. We also aimed to investigate differences between the responders and nonresponders to rTMS and what would predict clinical response to rTMS.
The specific aims of this study is to: (1) evaluate the antidepressant efficacy of rTMS on major depression; (2) evaluate the effects of rTMS on cognitive function in depressive patients; (3) assess the effects of rTMS on cerebral glucose metabolism in depressive patients as measured by 18FDG PET; (4) investigate the differences of the regional cerebral glucose uptake changes during rTMS between responders and nonresponders to rTMS.
Study Type
OBSERVATIONAL
Enrollment
40
10 times repetitive TMS, high frequency
Samsung Medical Center
Seoul, Kangnam-Ku, South Korea
RECRUITINGHamilton depression rating scale (HAM-D 17)
measuring instrument of severity of depressive symptoms
Time frame: baseline, 1, 2, and 4 weeks after TMS
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