Anemia and vitamin A deficiency (VAD) are major nutritional problems in the world and also in Myanmar. Both nutrient deficiencies result from interaction of several causal factors, and a better understanding of the etiology to interpret the prevalence and to formulate appropriate measures to reduce these deficiencies is necessary. There is a growing concern on the role of sub-clinical inflammation on the nutritional status indicators during the nutritional status assessment. However, there is lack of information on the role of inflammation on the iron supplementation. The adolescent period is a window of opportunity to improve the preconceptional iron status of the girls and recently gained much attention. The purpose of the study is to understand the role of inflammation on iron and vitamin A status during iron and vitamin A supplementation. The findings will show the extent to which iron supplementation has been hampered by inflammation and to formulate the necessary measures to overcome the interference.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
402
Ferrous fumarate, 60 mg, weekly dose
Retinol, weekly dose, 15,000 IU
Ferrous fumarate, Retinol combination group, weekly dose
folic acid only as placebo group
Nyaung Done Township
Pathein, Ayeyarwady Region, Burma
Haemoglobin Level
Haemoglobin level (g/L) measured by cyanmethaemoglobin method
Time frame: at week 0, week 6 and week12
Status of Tissue Iron Store
Tissue iron store was measured by serum ferritin
Time frame: at week 0, week 6 and week12
Status of Cellular Iron Deficiency
Cellular Iron deficiency status is also measured by serum transferrin receptor
Time frame: at week 0, week 6 and week12
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.