Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial

Inclusion Criteria: * at least 18 years of age, of either sex and any race * diagnosis of chronic rhinosinusitis with or without nasal polyposis according to the EPOS guidelines research * Subjects should be regularly scheduled for bilateral functional endonasal endoscopic sinus surgery * Subjects must be in good health, free of any clinically significant disease that would interfere with the study schedule or procedures or compromise his/her safety. * Subjects must be willing to give informed consent and adhere to visit schedules, medication restrictions, and agree to perform daily diary entries. * Nonpregnant women of childbearing potential must use a medically acceptable, adequate form of birth control. Exclusion Criteria: * Women must not be pregnant, breast feeding, or premenarcheal. * Subjects who have required oral corticosteroids within the previous four weeks prior to surgery. * Subjects who have required nasal corticosteroids within the previous one week prior to surgery. * Subjects with known allergic reaction on tetracyclines, diabetes (type 1 and 2), renal insufficiency, severe liver disease, systemic diseases affecting the nose (e.g. M. Wegener), prior surgeries of the paranasal sinuses. * Patients with the following diseases should be excluded : 1. Cystic fibrosis based on positive sweat test or DNA alleles 2. Gross immunodeficiency (congenital or acquired) 3. congenital mucociliary problems e.g. primary ciliary dyskinesia (PCD) 4. Non-invasive fungal balls and invasive fungal disease 5. systemic vasculitis and granulomatous diseases 6. Cocaine abuse 7. Neoplasia