Specific Oral Tolerance Induction to Cow's Milk Allergy

Inclusion Criteria: 1. -Infants between 24-36 months of age. 2. -IgE-mediated allergy to CMPs meeting all the following diagnostic criteria: * Immediate-type clinical manifestations, skin (urticaria, angioedema and/or erythema), digestive (acute vomiting and/or diarrhea) or respiratory (bronchospasm and/or rhinitis) involvement in the first two hours after cow's milk ingestion. * Skin test readings ≥ 3 mm and specific IgE titers \> 0.35 kU/l for whole cow's milk or someone of isolated CMPs (casein, alpha-lactalbumin, beta-lactoglobulin ) 3. -Persistence of CMP allergy in the four weeks prior to tolerance induction, based on the following criteria: * Skin (prick) test readings ≥3 mm and specific IgE titers (CAP-FEIA) \>0.35 kU/l for whole cow's milk or someone of isolated CMPs (casein, alpha-lactalbumin, beta-lactoglobulin ) * Double-blind placebo-controlled challenge (DBPCFC) positive to cow's milk. 4. -Written informed consent from the parents. Exclusion Criteria: 1. -Clinical manifestations of anaphylactic shock after the ingestion of cow's milk. 2. -Non-IgE-mediated or non-immunological adverse reactions to cow's milk. 3. -Malignant or immunopathological diseases and/or severe primary or secondary immune deficiencies. 4. -Patients receiving immunosuppressor therapy. 5. -Patients receiving beta-blockers (including topical formulations). 6. -Associated diseases contraindicating the use of adrenalin: cardiovascular disease or severe hypertension