POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

N/ACompletedNCT01199913

Loma Linda University110 enrolled

Overview

The use of desflurane in elderly subjects (\>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Study Type

OBSERVATIONAL

Enrollment

110

Conditions

1. Postoperative Cognitive Dysfunction

Interventions

The intervention will be Mini-Mental Status Examination (MMSE)OTHER

A questionnaire given to the study patient before and after the anesthetic at 1, 6 and 24 hours.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (\>65 years old) * Scheduled for elective surgery requiring general anesthesia at LLUMC HSH * Airway management expected to include endotracheal intubation * Expected surgical duration 120 to 240 minutes Exclusion Criteria: * Pre-existing significant psychiatric disease or mental status changes * Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease * Patient's weighing \>50% ideal body weight * Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet * Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet * Patients who have undergone a general anesthetic within the past 7 days * Patient refusal

Locations (1)

Loma Linda University

Loma Linda, California, United States

Outcomes

Primary Outcomes

POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

The primary outcome measure will be changes in cognitive function after anesthesia as measured by MMSE.

Time frame: Both groups will complete the MMSE at 1, 6, and 24 hours after the end of anesthesia or to disharge up to 7 days.

Secondary Outcomes

Secondary outcome measures will include: 1) time to extubation, anesthetic complications (e.g. coughing during extubation), 2) time to readiness for discharge from PACU, 3) length of hospital stay, and 4) any postoperative complications.

Time frame: 24 hours to 7 days

Data from ClinicalTrials.gov

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