Effect of Vitamin D Supplementation on Muscle Mass and Function

Phase 4CompletedNCT01199926

Purdue University34 enrolled

Overview

The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. The investigators hypothesis for these studies is that vitamin D supplementation enhances exercise-induced increases in strength and lean mass, potentially through enhancing insulin sensitivity and reducing inflammation.

The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. It was a double-blind, randomized, placebo-controlled, clinical trial with participants randomized into either a 4,000 IU/day vitamin D or placebo group and all participants completed 12 wks (3 d/wk) of exercise training.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Obesity Insulin Resistance Inflammation

Interventions

Vitamin DDIETARY_SUPPLEMENT

4000 IU of vitamin D per day for 12 weeks.

PlaceboDRUG

Placebo (microcrystalline cellulose) ingestion each day for 12 weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Physical activity scores in the "low" to "very low" category * Fitness estimations in the "below average" or lower categories * body mass index scores \>24.9 indicating overweight or obesity. Exclusion Criteria: * Use of tanning booths or other artificial UV light exposure * High baseline vitamin D and calcium intake * Plans to visit sunny/warm destinations during the winter months/study period * History or presence of metabolic disease, type 2 diabetes, eating disorders, gastrointestinal disorders, pregnancy or lactation * Use of drugs to treat obesity (last 12 weeks) * Use of over the counter anti-obesity agents (last 12 weeks) * Recent initiation of an exercise program (last four weeks).

Locations (1)

Wastl Human Performance Laboratory, Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

Muscle Function

The primary endpoint is the change in lean mass (kilograms) after the three month resistance exercise intervention.

Time frame: three months

Glucose Tolerance

The primary endpoint is the change in the area under the glucose curve following an oral glucose tolerance test prior to and after the three month intervention.

Time frame: three months

Inflammation

The primary endpoint is the change in C reactive protein after the three month intervention

Time frame: three months

Data from ClinicalTrials.gov

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