Bevacizumab Plus Somatostatin Analogue and Metronomic Capecitabine in Patients With Advanced Neuroendocrine Tumors

Inclusion Criteria: * Histologically or cytologically diagnosis of well-differentiated neuroendocrine carcinoma * Inoperable disease * Age \> 18 * ECOG Performance Status 0-2 * Life expectancy of at least 12 weeks * Measurable and/or evaluable lesions according to RECIST criteria * Radiological documentation of disease progression * Adequate bone marrow reserve * Adequate hepatic and renal function * Urine dipstick of proteinuria \< 2+ * Written informed consent * Comply with the protocol procedures Exclusion criteria: * Serious non-healing wound or ulcer * Evidence of bleeding diathesis or coagulopathy * Uncontrolled hypertension * Clinically significant cardiovascular disease for example cerebrovascular accidents (≤6 months), myocardial infarction (≤6 months), unstable angina, New York Heart Association (NYHA) grade II or greater congestive heart failure, serious cardiac arrhythmia requiring medication * Current or recent ongoing treatment with anticoagulants for therapeutic purposes * Chronic, daily treatment with high-dose aspirin (\>325 mg/day) or other medications known to predispose to gastrointestinal ulceration * Patients with severe renal impairment (creatinine clearance below 30 ml/min) * Other co-existing malignancies or malignancies diagnosed within the last 5 years with the exception of basal cell carcinoma or cervical cancer in situ * Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study treatment start, or anticipation of the need for major surgical procedure during the course of the study * Pregnant or lactating women.