Prediction of Jaundice in Term Infants

N/ACompletedNCT01203410

NICHD Neonatal Research Network535 enrolled

Overview

The objective of this study was to describe total bilirubin production in healthy term infants as a means of understanding the differences in jaundice pigment production associated with various common clinical circumstances.

Jaundice occurs in most human neonates during the several days after birth. The objective of this study was to describe total bilirubin production in healthy term infants as a means of understanding the differences in jaundice pigment production associated with various common clinical circumstances.

Study Type

OBSERVATIONAL

Enrollment

535

Conditions

Infant, Newborn Jaundice

Eligibility

Sex: ALLMax age: 8 HoursHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infants born via cesarean delivery (to ensure subjects would still be hospitalized and available for ETCOc measurement and blood sampling on day 3 postpartum) * Delivery within each center's scheduled recruitment period (to maximize nursing availability and minimize cost) * Birth weight \>2500 g * Gestational age \>37 weeks Exclusion Criteria: * Any illness that would require admission to the neonatal intensive-care unit (NICU) within 8 hours of birth

Locations (13)

Stanford University

Palo Alto, California, United States

Yale University

New Haven, Connecticut, United States

George Washington University

Washington D.C., District of Columbia, United States

Outcomes

Primary Outcomes

End-tidal carbon End-tidal carbon monoxide levels corrected for ambient air (ETCOc)

An index of bilirubin production

Time frame: 2-8 hours of age

Data from ClinicalTrials.gov

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