Valproic Acid With Chemoradiotherapy for Non-Small-Cell Lung Cancer

Inclusion Criteria: 1. Age \> 18 years. 2. Newly-diagnosed, histologically or cytologically confirmed NSCLC. 3. Inoperable stage IIIA-B disease 4. KPS \> 60 5. FEV1 \>1.2L 6. No previous RT to chest 7. No serious comorbid condition 8. No treatment with biological response modifiers or cytotoxic agents within four weeks prior to study entry 9. No participation in clinical trial using any investigational drug or device within four weeks prior to study entry 10. No serious complication of malignant condition 11. No previous or concurrent malignancy at other sites except cone biopsied in situ carcinoma of the uterine cervix and adequately treated basal cell or squamous cell carcinoma of the skin 12. Adequate organ function as evidenced by the following peripheral blood counts or serum chemistries at study entry: Hemoglobin \> 9.0 Gm/dL WBC count \> 4.0x109/L Neutrophile count \> 1.5 cells x 109/L, Version 1, May 12, 2010 Platelet count \> 100 x 109/L, Creatinine \< 1.5 mg/dL Total bilirubin \< upper limit of normal (ULN) AST/SGOT \< ULN Calcium \< ULN 13. Ability to sign informed consent 14. Ability to attend follow-up visits Exclusion Criteria: 1. Operable disease 2. Metastases to contra-lateral mediastinal lymph nodes 3. Distant metastases 4. KPS \< 60 5. FEV1 \< 1.2L 6. Previous RT to chest 7. Treatment with biological response modifiers or cytotoxic agents within four weeks prior to study entry 8. Participation in clinical trial using any investigational drug or device within four weeks prior to study entry 9. Major surgical procedure within two weeks prior to study entry 10. Serious comorbid condition, inclusive but not limited to myocardial infarction within previous six months, uncontrolled cardiac arrhythmias, uncontrolled angina pectoris, active infection including acute hepatitis 11. Serious complication of malignant condition 12. Previous or concurrent malignancy 13. Inadequate organ function as evidenced by the following peripheral blood counts or serum chemistries at study entry: Hemoglobin \< 9.0 Gm/dL WBC count \< 4.0x109/L Neutrophile count \< 1.5 cells x 109/L, Platelet count \< 100 x 109/L, Creatinine \> 1.5 mg/dL Total bilirubin \> ULN (upper limit of normal) AST/SGOT \> ULN Version 1, May 12, 2010 Calcium \> ULN 14. Inability to sign informed consent 15. Psychological, familial, sociological or geographical conditions which do not permit regular medical follow-up and compliance with the protocol