The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery

N/AUnknownNCT01204268

Xijing Hospital80 enrolled

Overview

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Brain Ischemia

Interventions

Sev-I groupPROCEDURE

Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.

Sevo continuous inhalationPROCEDURE

Patients will receive the anesthesia with continuous inhalation of sevoflurane.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient under intracranial aneurysm surgery. Exclusion Criteria: * Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.

Locations (1)

Xijing Hospital

Xi'an, Shaanxi, China

RECRUITING

Outcomes

Primary Outcomes

S-100B,NSE

Time frame: 7 days

Secondary Outcomes

Karnofsky Performance Scale,NIH stroke index, MMSE

Time frame: 6 months

Data from ClinicalTrials.gov

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