Medications Development for the Treatment of Cannabis Related Disorders

Inclusion Criteria: * Must meet DSM-IV/ICD-10 criteria for cannabis abuse or dependence * Must be non-treatment seeking individuals * Participant does not meet DSM-IV criteria for any current (i.e., criteria met at any point in the past 30 days) dependence on a substance other than alcohol, nicotine, caffeine, or marijuana or physiological dependence on alcohol requiring medical detoxification. * No subjects who have trouble reading the English language or visual or hearing problems that may interfere with the collection of data * Not currently taking other medications (with the exception of oral contraceptives) that would preclude safe participation in this study * Must test negative for pregnancy prior to inclusion * females using birth control pills must agree to use a condom during intercourse for 1 month after participation in study because the study medication will decrease the effectiveness of the birth control pill rendering it ineffective * Should be in general good health * No evidence of recent use of other illicit drugs on a urine toxicity screen prior to admission Exclusion Criteria: * Major current (within last 90 days) Axis I psychopathology (e.g., major depressive disorder, bipolar disorder, schizophrenia) * Presence of significant medical illness (e.g., diabetes, cardiovascular disease, hypertension, cancer, epilepsy, kidney disease) * Current, repeated illicit drug use (other than marijuana) * Subject is breastfeeding or pregnant * Concurrent therapy with drugs known to inhibit CYP3A4 activity * Request for drug treatment * Current parole or probation * Recent history of significant violent or suicide behavior * Allergic to sesame oil