Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients

Phase 4CompletedNCT01206153

Central South University84 enrolled

Overview

Antipsychotics such as risperidone could induce amenorrhea in schizophrenic patients. The investigators conducted a randomized, placebo-controlled study to test the efficacy of metformin for antipsychotic induced amenorrhea in schizophrenia patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

QUADRUPLE

Enrollment

Conditions

Amenorrhea

Interventions

metforminDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * schizophrenia patient * amenorrhea for more than three months after antipsychotic treatment Exclusion Criteria: * liver or renal diseases * pregnant or lactating women * cardiovascular diseases * hypertension or diabetes mellitus

Locations (1)

Institute of Mental Health of The Second Xiangya Hospital, Central South University

Changsha, Hunan, China

Outcomes

Primary Outcomes

prolactin level

the outcome measure assess a efficacy.

Secondary Outcomes

fasting glucose

Data from ClinicalTrials.gov

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