Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor

Inclusion Criteria: * Histologically confirmed diagnosis of recurrent PVNS ( or diffuse-type giant cell tumor or tenosynovial giant cell tumor) that is unresectable, metastatic, or for which the patient refuses surgical intervention * Progressive disease in the last 12 months, as demonstrated by imaging or clinical appearance of new tumors, in the opinion of the treating investigator * At least one site of measurable disease according to RECIST 1.1 on MRI (or CT scan for metastatic disease) * Any number or type of prior systemic therapies, with the exception of known or suspected CSF1 receptor inhibitors as outlined in exclusion criteria below * 18 years of age or older * Life expectancy greater than 6 months * ECOG Performance Status of 0, 1 or 2 * Normal organ and marrow function as defined in the protocol * QTc less than or equal to 450 ms on 12-lead ECG * Negative urine or serum pregnancy test within days of start of study drug administration for women of childbearing potential. * Women of childbearing potential and men must agree to use adequate contraception prior to study entry, for the duration of study participation, and for 3 months following study drug discontinuation Exclusion Criteria: * Prior treatment with known or suspected CSF1 receptor inhibitor, including nilotinib, imatinib, sunitinib, or sorafenib, or other approved or investigational tyrosine kinase inhibitors used for treatment of diffuse-type giant cell tumor * Concurrent treatment with other investigational agents * Inability to tolerate or contraindication to MRI scanning for participants with localized disease * Impaired cardiac function * Current treatment with strong CYP3A4 inhibitors that cannot either be discontinued or switched to a different medication prior to starting study drug * Current treatment with any medications that have the potential to prolong the QT interval and that cannot either be discontinued or switched to a different medication prior to starting study drug * Impaired gastrointestinal (GI) function or GI disease that may significantly alter the absorption of study drug * Acute or chronic pancreatic disease * Acute or chronic liver disease * Another primary malignant disease requiring systemic treatment or radiation * History of significant congenital or acquired bleeding disorder unrelated to cancer * Major surgery within 28 days prior to Day 1 of the study * Treatment with other investigational agents within 28 days of day 1 * History of non-compliance to medical regimens or inability to grant consent * Women who are pregnant or breastfeeding * Other comorbidities that would interfere with study participation or safety in the opinion of the investigator