Post Cond No Reflow

N/ACompletedNCT01208727

Hospices Civils de Lyon44 enrolled

Overview

After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Myocardial Reperfusion Injury

Interventions

postconditioningPROCEDURE

Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients \> 18 years old, * Male or female, * Presenting first myocardial infarction, with the beginning of pains \< 12 hours, * Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA). * Artery guilty with TIMI flow = 0 Exclusion Criteria: * cardiac arrest before the angioplasty, * Cardiogenic shock * Occlusion of the artery circumflex responsible for the infarction * Magnetic resonance imaging: contre indication

Locations (1)

Hospices Civils de Lyon

Lyon, France

Outcomes

Primary Outcomes

Extent of the area of microvascular obstruction

Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group

Time frame: 5 days

Secondary Outcomes

Size of the myocardial infarction

Size of the myocardial infarction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group.

Time frame: 5 days

Data from ClinicalTrials.gov

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