Metformin should be administered with caution and could be potentially dangerous in infertile patients with PCOS who show a poor ovarian response and are undergoing gonadotropin-based ovarian stimulation. However, data that address this point are totally lacking. On the basis of these considerations, the aim of the current clinical trial was to test the hypothesis that metformin reduces the ovarian response in infertile patients with PCOS who have a potentially poor ovarian response and who undergo gonadotropin stimulation for IVF cycles.
Primary infertile patients with PCOS older than 35 years and/or with a basal follicle-stimulating hormone (FSH) level higher than 10 IU/L who were scheduled for IVF cycles were enrolled in the study protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
88
Pugliese" Hospital
Catanzaro, Italy, Italy
Rate of cancellation due to low ovarian response
Number of cancelled cycles/total cycles
Time frame: one month
Stimulation length
Time frame: one month
Gonadotropins dose
Time frame: one month
Ovulation rate
Time frame: one month
pregnancy rate
Time frame: one month
Live-birth rate
Time frame: nine months
Adverse effects
Time frame: one month
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