A Feasibility Study On Continuous Adaptive [18f]Fdg-Pet-Guided Radiotherapy For Head and Neck Cancer

Inclusion Criteria: * Histologically confirmed squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx or larynx. * Primary unresectable tumor and/or patients refused surgery. * Stage T1-4; T3-4 N0 or Tany N1-3 for cancer of the glottis. * Multidisciplinary decision of curative radiotherapy or radiochemotherapy. * Karnofsky performance status ≥70%. * Age ≥ 18 years old. * Informed consent obtained, signed and dated before specific protocol procedures. Exclusion Criteria: * Treatment combined with brachytherapy. * Prior irradiation to the head and neck region. * Distant metastases. * Second primary tumors that are not under control * Pregnant or lactating women. * Creatinine clearance (Cockcroft-Gault) ≤ 60 mL/min before treatment. * Allergy to the CT-contrast agents. * Mental condition rendering the patient unable to understand the nature, scope, and possible consequences of the study. * Patient unlikely to comply with protocol, i.e. uncooperative attitude, inability to return for follow-up visits, and unlikely to complete the study.