Durolane Versus Methylprednisolone in Knee Osteoarthritis

Inclusion Criteria: * Subject (female or male) 35-80 years of age * Unilateral knee pain * Radiographic evidence of OA * WOMAC pain score of 7-17 * Subject normally active * Subject has attempted but not responded adequately to previous non-pharmacological therapy(ies); * Subject cooperative and able to communicate effectively with the investigators; * Body mass index ≤ 40 kg/m2; * Signed informed consent obtained. Exclusion Criteria: * Knee effusion * Contralateral knee OA * Clinically significant joint pain from joints other than the knee * Previous intra-articular steroid injection into the study knee within the last 3 months; * Previous intra-articular HA injection into the study knee within the last 9 months; * Previous allergic type reaction to a HA product, a steroid, or lidocaine/related anesthetics; * Treatment with analgesics other than paracetamol (acetaminophen) (including topical agents for the knee) within 5 half lives of the drug prior to the baseline visit; * Use of systemic glucocorticosteroids (excluding inhaled steroids) within the last 3 months; * Treatment with glucosamine/chondroitin sulfate initiated within the past 3 months * Change in physical therapy for the knee within the last three months * Arthroscopy or other surgical procedure in the study knee within the past 12 months; * Any planned arthroscopy or other surgical procedure during the study period; * Previous history or presence of active septic arthritis * Active skin disease or infection in the area of the injection site; * Systemic active inflammatory condition or infection * Bleeding diathesis or use of anticoagulants * Current uncontrolled diabetes mellitus; * Any medical condition that in the opinion of the investigator makes the subject unsuitable for inclusion * Pregnant or breastfeeding woman or woman of childbearing potential not practicing adequate contraception; * Involvement in other clinical trials