The purpose of the study is to determine if inhaled iloprost given four times daily can improve symptoms and lung function in adults with mild asthma.
Animal studies have suggested that prostacyclin may downregulate allergic inflammation, thus providing the scientific basis for trials of inhaled prostacyclin agonists such as iloprost for the treatment of asthma. This study will examine the tolerability of four times daily iloprost on asthma symptoms and pulmonary function over a two week treatment period.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Masking
NONE
Enrollment
24
Inhaled iloprost 2.5 or 5 micrograms four times daily for 14 days
Vanderbilt University Medical Center
Nashville, Tennessee, United States
PD20FEV1 methacholine
Provocative dose of methacholine resulting in a 20% fall in FEV1 from baseline
Time frame: two weeks
asthma related symptoms
Asthma quality of life questionnaire; Juniper
Time frame: 4 weeks
asthma control
Juniper asthma control test score
Time frame: 4wks
FEV1
Forced expiratory flow in one second
Time frame: 2wks
Exhaled nitric oxide
Measurement of exhaled nitric oxide
Time frame: 2 wks
Interleukin 17
ELISA measurement of serum interleukin 17
Time frame: 2wks
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