Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved. There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
exercise training min. 4 times a day for at least 30 min
Intensive exercise training for 4 times / day incl. interval training at 95% individual threshold
Heart Center Leipzig- University Leipzig
Leipzig, Germany
coronary collateral blod flow
Time frame: 4 weeks
plaque composition within the coronary artery
plaque composition measured by virtual histology intravascular ultrasound
Time frame: 4 weeks
MACCE
major cardiovascular events (death, myocardial infarction, stroke, TIA, coronary revascularisation, hospitalisation)
Time frame: 4 week, 6 months, 12 months
atherosclerosis parameter within the laboratory
e.g. wie hs-CRP, HDL, LDL, ges. Cholesterin, Triglyceride, Zytokine, Adipokine, Endocannaboide
Time frame: 4 weeks, 3, 6, 12 months
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