The investigators hope to see if a commonly used drug such as ketamine could help depressed ER patients feel better and improve their mood quickly.
Rapid-onset antidepressants could have important clinical impact if their benefits extended to Emergency Department (ED) patients. We hope to explore the preliminary feasibility, tolerability and efficacy of single-dose, intravenous (IV) ketamine in depressed ED patients who presented with suicide ideation (SI). The manuscript (article) for this study has been retracted because Yale University conducted an investigation that determined that the description of the research was not accurate. The article misrepresents both the protocol-specified doses and the actual delivered doses of ketamine.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
14
intravenous ketamine(0.2 mg/kg) over 1-2 minutes IV
Yale New Haven Hospital Emergency Department
New Haven, Connecticut, United States
Montgomery Asberg Depression Rating Scale (MADRS)
The MADRS measures mood (depression) and item 10 measures suicide ideation.
Time frame: 40, 80, 120, 240 minutes after administration of drug
recruitment success and retention of subjects in the ER
All patient subjects are admitted and we will follow them in the hospital and for 2 weeks after hospital discharge.
Time frame: initial recruitment of eligible subjects in the ER and for two weeks after administration of drug
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