Physiological Brain Atlas Development

Ohio State University456 enrolled

Overview

Enrollment of candidates undergoing a deep brain stimulator (DBS) implant.

The study proposes the enrollment of candidates undergoing a deep brain stimulator (DBS) implant. Data will be collected before, during and after surgery and will be electronically entered into the Atlas database where it will be stored indefinitely. The purpose of the study is to create an Atlas to store physiological information utilizing non-rigid MRI normalization algorithms. In addition to collating and analyzing the physiological atlas in a statistical manner that allows the surgeon to predict optimal targeting locations for DBS implants based on multiple physiological variables, including pre-operative severity of disease, intraoperative neurophysiological observations, and post-operative response to DBS stimulation therapy.

Study Type

OBSERVATIONAL

Enrollment

456

Conditions

Parkinson Disease Dystonia Tremors Obsessive Compulsive Disorder Depression

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 7 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Any patient between the age of 7-90 * Patients who have undergone deep brain stimulation (DBS) surgery as standard of care at The Ohio State University Exclusion Criteria: * None

Locations (1)

The Ohio Sate University

Columbus, Ohio, United States

Outcomes

Primary Outcomes

optimal DBS target location

To create an atlas that will allow physiological information to be assigned to anatomical locations in MRI space, utilizing non-rigid MRI normalization algorithms.

Time frame: intra-operative identification

Data from ClinicalTrials.gov

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